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Oligonucleotide Drugs

Oligonucleotide drugs （OND）are a general term for a class of short-chain nucleotide compounds consisting of bases that are recognised and bound to the target nucleotide sequence through the Watson-Crick base-pairing principle, interfering with the transcription and translation of disease-causing genes, thereby correcting the expression of disease-causing proteins and ultimately achieving the effect of treating disease.

According to the differences in drug structure and mechanism of action, OND can be classified:

Antisense oligonucleotide (ASO).

Small interfering RNA (siRNA).

micro-RNA (miRNA).

Aptamer, etc.

2’-O-Methyl phosphoramidites

2’-Fluoro phosphoramidites

2’-O-MOE phosphoramidites

2’-O-TBS phosphoramidites

LNA phosphoramidites

GalNAc series

2'-F amidites

2'-O-Methyl amidites

2'-O-MOE amidites

2'-O-TBDMS amidites

LNA phosphoramidites

GNA phosphoramidites

UNA Phosphoramidites

PMO phosphoramidites

GalNAc

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